Ultimately, my vet did not recommend we go down that route. Discount Prices on Pet Supplies, Nexgard, Bravecto, Trifexis, Simparica TRIO, Apoquel, and more. Banovic F, Tarigo J, Gordon H, et al. Option 3 is using a nebulizer with dexamethasone and/or other drugs. Each dosage is sold per tablet, in 20 count, or 100 count bottles. 1. If she stays the way she is now, I will play with spacing it out furtherfirst with every 2 days. This is totally random but figured Id mention it since I had no idea till I saw someone mention itZoetis has a rewards program and Apoquel is one of the drugs on it. Many of these cytokines bind to cytokine receptors that have JAK enzymes associated with their cytoplasmic portion. So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. The second option is serum (blood) testing. Vet Dermatol 2017;28(5):485-e113. What company did you use? Since some horses have both "types" of asthma, you may need to try a stall without bedding, or experiment with different types of bedding. This study showed that pruritus was improved in only 42% of the study population; thus, use of oclacitinib in cats did not seem to be as effective as in dogs.17 A follow-up study was conducted with a higher dose (0.7 to 1.2 mg/kg) and a longer induction period (28 days). Vet Dermatol 2016;27(Suppl 1):100 (abstract). With equine allergies, prevention is a horse owners best bet. Interestingly, the results suggest that oclacitinib has immunosuppressive properties, but only at a higher dosage than that approved on the label.30. There are a few medication protocols for horses with Equine Asthma. Weve also been able to start rehabbing back into work. 21. Dosing Chart Warnings Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction.11 Little et al compared oclacitinib to cyclosporine. 4. If you struggle to get your dog to take tablets, you can try hiding it in their food, or wrapping it in a tasty piece of meat. But Im not sure how much the long term cost will be yet. This is a new treatment option, and currently the tablets are not FDA approved for horses, only dogs. KER offers EO3, which contains the omega-3 fatty acids DHA and EPA. Although no studies of pharmacokinetics in cats have been published, oclacitinib is well tolerated and seems to be safe when used in cats at 1 or 2 mg/kg q12h for 28 days.21 Further studies are needed to investigate adverse effects associated with long-term use in cats. Transdermal applicator that gives easy & accurate dosing every time. If you must give corticosteroids to an asthmatic horse, your veterinarian might prescribe them to be administered via an aerosol route through the nostril (rather than orally or via injection), which minimizes the amount that gets into the general circulation. Do not use in breeding, pregnant, or lactating dogs. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel) in client-owned dogs with atopic dermatitis. Oclacitinib is available in 3 different tablet sizes: 3.6, 5.4, and 16 mg. Apoquel should be shipped with extreme caution when temperature is below 35 degrees Fahrenheit. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. Genome Biol 2004;5(12):253. The efficacy and safety of oclacitinib have been assessed in various studies. Atopic dermatitis is often a complex disease that requires a multifaceted approach. Little PR, King VL, Davis KR, et al. Do not use in breeding, pregnant, or lactating dogs. The recommended dosage of Apoquel 3.6mg tablets is 0.18 to 0.27 milligrams per pound of body weight. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. Veterinarians dose Apoquel at 0.18-0.27mg per pound of bodyweight. Old fashioned drugs like Benadryl and steroids don't work well any more. Submit Office Orders & Patient Prescriptions. Gonzales AJ, Humphrey WR, Messamore JE, et al. Apoquel starts working within 4 hours of administering the first dose and controls itching within 24 hours. It definitely makes them more comfortable. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days.7,8 Treatment success was based on reductions from baseline of at least 2 cm on the owner-assessed visual analog scale and at least 50% on the clinicians Canine Atopic Dermatitis Extent and Severity Index (CADESI-02). 3. Thereafter the dose should be reduced to once daily for maintenance. Clenbuterol dilates the airways, and may improve air flow, but it doesn't treat the inflammation associated with the disease. See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). Currently, White is part of a team evaluating the possibility of delivering allergy shots in the form of a juice squirted under the horses tongue. Remove all nonessential supplements and topical solutions from your horses diet and routine. Therefore, in many of these cases, veterinarians use steroids sparingly, says Fultz, at lower doses than recommended, or they turn to non-steroidal medications. The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. 1,2 The #1 prescribed medicine for allergic itch in dogs. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. If your horse's test results (from a BAL or tracheal wash) show a certain cell type in the lungs, we may recommend trying Zyrtec!Clenbuterol: This is a bronchodilator that may be beneficial in treating some horses with Equine Asthma. So I think cost becomes dependent on that. Fultz adds that over time this process teaches the immune system to tolerate exposure to substances it previously considered irritating. Therefore, the recommended initial dosage for dogs 6.6-9.9 lbs is of a 3.6 mg tablet twice daily. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. By blocking cytokines, Apoquel blocks your dog's skin from itching and inflammation. The second option is serum (blood) testing. Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Treatment may then be continued at the same dose given once a day. Read on below! APOQUEL may be administered with or without food. The dose of Apoquel tablets is 0.18 to 0.27 mg/lb of body weight. If your horse has "classic" RAO, he may have more difficulty in the barn, and need to be kept outside 24/7.3: The Supplements: Studies have shown that horses with Asthma benefit from supplements with Omega 3 fatty acids. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. And I am debating spreading even further to every 2 days to see how she does, but I am a bit nervous to do so, especially when its so hot. May be used with other common medications. Fortunately, these side effects are relatively uncommon. This product came to the market in the US in Fall 2020. Fukuyama T, Ganchingco JR, Bumer W. Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib. In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. Now divide the 10,000 mg by the 500 mg in the concentration. Vet Dermatol 2017;28(5):512-e123. BMC Vet Res 2019;15(1):137. Oclacitinib was well tolerated in both studies. Collard WT, Hummel BD, Fielder AF, et al. Ortalda C, Noli C, Colombo S, et al. Apoquel can only be obtained with a prescription; it is available as film-coated tablets and chewable tablets in different strengths to cover a range of dog weights. Stay up-to-date on the latest news about your horse's health with FREE newsletters from TheHorse.com. ACVIM, a Florida-based large animal internal medicine specialist with an interest in respiratory disease. Dosage and Administration: The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Your veterinarian might also prescribe corticosteroids such as dexamethasone or prednisolone, which provide fast and effective relief from immune-mediated conditions such as allergies because of their immunosuppressive properties. Qualifies for Zoetis Petcare Rewards! More severe ones, however, can truly take a toll on your horses health and make him miserable. As the only FDA-approved equine PSGAG (polysulfated glycosaminoglycan) for degenerative joint disease (DJD) in horses, Adequan i.m. 19. Treatment should be started at a dose of 0.4 - 0.6 mg per kilogram bodyweight twice a day for up to two weeks. 7. 2. The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies. Some allergic reactions are unexpected, as White has realized through his research. Cost for the initial course of treatment (about 12 days) will be around $300-400. Once you have the horse's symptoms under control, you can try re-introducing hay. Search term . Its expensive, but its working. Bursatti, Leeches) in Dogs, Cats and Horses. Horse dosing is 5 pills. Allergies are generally managed based on the severity of clinical signs. After completing a doctorate thesis and a rotating internship at the University of Zurich, Switzerland, he moved to the United States, where he completed a 3-year veterinary dermatology residency at the University of Georgia in 2004. The Janus kinases (Jaks). Use of them does not imply any affiliation with or endorsement by them. Six adult horses with a mean weight of 528 kg were administered a single dose of 0.5 mg/kg oclacitinib maleate. Lucile Vigouroux holds a masters degree in Equine Performance, Health, and Welfare from Nottingham Trent University (UK) and an equine veterinary assistant certification from AAEVT. To overcome its delayed effect, cyclosporine is often initially combined with other drugs such as prednisolone to accelerate the anti-inflammatory and antipruritic effects. 7. Vet Dermatol Vet Dermatol 2013;24:48-e12. Lopes NL, Campos DR, Machado MA, et al. Haugh IM, Watson IT, Menter MA. 30. EHV Quarantine Released at Turf Paradise Racetrack, Six Simple Spring Safeguards for Senior Horses, Evaluating the Suspensory Ligament in Cutting Horses, Regular Dental Care Important in Horses Worldwide, Investigating Equine Cases of Toxicant Exposure, Podotrochlosis: Navicular is No Longer the End of the Road for Horses. Apoquel is a prescription medication used to treat itching and inflammation in dogs. Your Price: $2.20. On the topic of simple and economical allergy management, a readily accessible ingredient that helps many horses is flaxseed. J Zoo Wildl Med 2017;48(3):818-828. Equine Asthma- yep, that's the new name for "heaves," "RAO," "COPD" or whatever else we've called it over the years! In atopic dermatitis, it is mainly mediated by a large group of proinflammatory and proallergic Th2 cytokines (e.g., interleukin [IL]-4, IL-5, IL-10, IL-13, IL-31). $ 78.30 - $ 245.00. Unless my vet (and an unaffiliated nutritionist) I consulted are wrong-- I was told that allergy serum is only possible/effective for some allergies and a lot of food-based ones are not on the list. Left untreated, these conditions can not only cause discomfort but also lead to raw, broken skin that allows bacteria to invade and infect. 26. Olivry T, Banovic F. Treatment of canine atopic dermatitis: time to revise our strategy? Use of oclacitinib (Apoquel; Zoetis) for treatment of cutaneous mastocytosis in a cat. We have limited her exposure to the type of grass that she is most allergic to (bermuda), but it is hard to actually remove her exposure to her allergens entirely. IgE binds to cells in the body and releases inflammatory molecules. 3 Can be used for long-term maintenance or short-term therapy in dogs 12 months of age . Specifically, studies in cats have used the following dosage: Initially, doses ranging from 0.4 to 1.2 mg/kg body weight, twice daily, for 24-28 days. Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. Apoquel is sold per tablet in strengths of 3.6 mg, 5.4 mg, or 16 mg. So new drugs such Atopica and Apoquel are prescribed routinely, to help dog owners find a quick fix for dog allergies. Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. We have had variable results with this treatmet. Veterinarians are especially wary of administering corticosteroids to allergic horses that suffer from pituitary pars intermedia dysfunction, insulin dysregulation, and/or equine metabolic syndrome, because these conditions are also risk factors for laminitis. Feline idiopathic ulcerative dermatosis treated successfully with oclacitinib. This medication may be a very good option for minis, since the costs will be much lower. Oral . Little PR, King VL, Davis KR, et al. Table of Contents hide Apoquel dosage for dogs chart Apoquel for Dogs Reviews: Does It Really Work? Dosage and administration For oral use. And some can got a lower dose or a further spread out dose. During this period, the drug is administered twice daily, with an interval of 12 hours. Most common side effects are vomiting and diarrhea. Recently, researchers have delved into the causes and consequences of what now falls under the umbrella term equine asthma. "Even though the drug is currently labeled for use in dogs (with. Apoquel (oclacitinib tablet) Dosing & Administration How to dose Apoquel 0.4-0.6 mg/kg (0.18-0.27 mg/lb) Twice daily (BID) for up to 14 days Continue therapy once daily (SID) thereafter for maintenance May be given with or without food May discontinue without tapering Apoquel Dosing Guide Weight Range (lb) Number of Tablets to be Administered If the diagnosis is wrong or the medication affects the horse adversely, you could endanger your horse's life. Apoquel should be administered orally, twice daily for up to 14 days, and then once daily for maintenance therapy. The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog. Adv Vet Dermatol 2017;8:192-198. A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. Most horses in our area of North Carolina are "Summer-Pasture-Associated" asthma patients, so we recommend starting yearly treatment or management in March or April. Vet Dermatol 2014;25(6):512-518. Vet Dermatol 2015;26(3):171-179, e35. Thank you! Apoquel is not FDA approved to use twice daily longer than 14 days. 10. Many allergic reactions are evident as a mild case of transient hives. She reports choosing Apoquel over corticosteroids in several of her allergic patients that are also at risk for developing laminitis. Ive used it on a couple of mine, and I also have some friends who have done it. Gonzales AJ, Bowman JW, Fici GJ, et al. Loft K, Simon B. The biggest disadvantages are the cost, the need to acclimate the horse to having the device placed in his or her nostril, poor tolerance by some horses who dislike the device, and the uncertainty about how long your horse will be able to go without repeating the treatment. Im hopeful, however, that I will be able to stretch out more so that Im looking at $250 across 8-10 weeks instead. Thats def not nothing but its not insane. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. These are known as allergy shots. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. This content is intended for counseling purposes only. Pollen and other plant-based aeroallergens are the source of their distress, and they fare much better inside a well-ventilated barn. Cats have been reported to drink more water while receiving this drug and also experience be- havior changes while receiving hydroxyzine. If she suspects a product or ingredient to be the source of an allergic reaction, Fultz recommends performing elimination trials. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Apoquel comes in tablet form only. Apoquel is a non-hormonal drug for dogs, used for dermatitis of various etiologies, which are accompanied by itching. Dosage Chart Urticaria (hives) is the most widely reported presentation of a skin allergy. The anti-inflammatory/immunosuppressive response is confined almost exclusively to the lungs, avoiding a bodywide effect, says Fultz. Diphenhydramine can alter the results of skin allergy testing; discontinue this medication at least 2 weeks before testing. Yamaoka K, Saharinen P, Pesu M, et al. 8. Minimum order 6 tablets per dosage. Why Do Some Horses Develop Respiratory EHV-1 and Others EHM? Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. You'd do anything for your pet. Until recently, glucocorticoids (systemic and/or topical) and cyclosporine have been considered the most effective symptomatic treatment options to manage atopic dermatitis. While easy to perform, Fultz says its not always accurate at predicting the exact allergens. 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. Even though the drug is currently labeled for use in dogs (with allergic dermatitis), initial studies show that horses absorb it well, Fultz says. While oclacitinib is a very effective and fast-acting antipruritic drug, the decision of when to use it depends on various factors. It is no surprise we see this omega-3-rich plant with anti-inflammatory and antioxidative properties in many skin and allergy supplements. Owners using a nebulizer will also have to replace the medication cups on the nebulizer every few months, at a cost of about $80 per cup. Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. 2. This includes dietary supplements, shampoos, liniments, fly sprays, coat conditioners, etc. Posted by Lucile Vigouroux | May 4, 2022 | Article, Diseases and Conditions, Farm and Barn, Hives & Skin Allergies, Horse Care, Medications, Nutrition, Seasonal Care, Skin Problems. Because its essentially impossible to predict these events, its important to keep records of your horses previous reactions and communicate them to your veterinarian.